EFFICACY OF THROMBOLYTIC THERAPY IN PRESERVING LEFT VENTRICULAR FUNCTION FOLLOWING ACUTE MYOCARDIAL INFARCTION

Abstract

This study is a prospective study to determine the value of thrombolytic agents in restoring patency in the
infarct related artery and its consequent effect on left ventricular function. At total of 48 patients were
investigated, all presenting with symptoms of chest pain. Clinical, electrocardiography and
echocardiographic criteria were used to document myocardial infarction. 2-D and M-mode
echocardiography was used to detect abnormalities of contraction and relaxation of myocardium. Two group
of patients were formed giving thrombolytic and non thrombolytic therapy.
Echocardiography was done on admission, discharge and three weeks after discharge from hospital. Patients
in both group were evaluated for clinical signs of left ventricular dysfunction according to Killip criteria. The
study showed a better left ventricular function in group receiving thrombolytic therapy. Patients who could
not be given thrombolytic therapy showed deteriorating left ventricular function which progressed even after
one week.
It is concluded that addition of thrombolytic therapy definitely improves left ventricular function by
restoring patency of infarct related artery, and thereby improving perfusion of ischemic myocardium.