ASSOCIATION OF HYPERURICEMIA WITH CRITICAL CORONARY ARTERY DISEASE

Gul Zaman Khan Niazi, Jehan Zab, Fahar Adnan, Nisar Ahmed, Ammar Akhtar, Muhammad Sohail Saleemi

Abstract


Objective: The study was conducted to determine the association of increased serum Uric acid level (SUA) with critical coronary artery disease (CAD) in patients subjected to coronary angiography.

Methodology: 360 patients (180 cases with critical CAD and 180 controls without critical CAD) were enrolled in the study after taking informed consent. Demographic data like age, gender, diabetes mellitus, hypertension, family history of CAD, dyslipidemia, smoking and BMI was collected. Serum uric acid was advised and recorded in the questionnaire.

Results: 360 patients with mean age 51.37 ± 6.5 years were included. 262 patients (72.8%) were male. 54 patients (20.8%) had hyperuricemia.  26.6% cases and 15.0% controls had hyperuricemia. Hyperuricemia was significantly associated with critical CAD (OR=2.06, CI 1.22-3.49, p=0.007). The association persisted after stratification according to age, gender, diabetes, hypertension, dyslipidemia, smoking, family history of IHD and BMI.

Conclusion: There is a positive association between critical CAD and hyperuricemia.

Keywords: Coronary artery disease, Hyperuricemia, IHD


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