Genotoxic effects of Lambada-cyhalothrin& Dimethoateon adult Male RatsFertility

Abstract

Background: Continuous use of pesticides could have adverse effects on the reproductive functions of humans and non-target organisms.Objective: This study was carried out to examine the effect of Lambada-cyhalothrin & Dimethoateon the reproductive parameters of adult male albino rats.                                                                                                                                  Methods: Forty (40) adult male Wistar albino rats weighing between 180 – 200g were divided into 5 groups of 8 animals each. Two groups were given Lambada-cyhalothrin (20, 40mg/kg) respectively, and Two groups were given Dimethoate (20, 40mg/kg) respectively. The control group was given drinking water. All treated daily by oral gavage for 30 days. Results: The results indicated the presence of a significant decrease (P<0.05) in the number of sperms and a significant increase in the number of abnormal spermatozoa in rats exposed to Lambada-cyhalothrin & Dimethoatewhen compared with control group, treated with drinking water.There were significant reductions (p<0.05) inon sex hormones level which includingfollicle-stimulating hormone (FSH), luteinizing hormone(LH) and testosterone levels in  male rats exposed to Lambada-cyhalothrin & Dimethoatewhen compared with control group, which treated with drinking water.The testicularhistology of animals treated with Lambada-cyhalothrin & Dimethoategenerally showedtubular atrophy with loss of spermatogenesis, the effect grading as mild in cases loss of spermatogenesis. The results confirmed that dimethoate seriously deteriorate the malereproductive system resulting in decreased fertility.