CORRELATION OF AGE AND DEFECT SIZE OF ISOLATED SECUNDUM ATRIAL SEPTAL DEFECT WITH PULMONARY ARTERY PRESSURE

Abstract

Objective: To find out correlation of age and defect size of isolated secundumatrial septal defect with pulmonary artery pressure measured by cardiaccatheterization.

Methodology: It was a cross-sectional study conducted at Cardiologydepartment, Lady Reading Hospital, Peshawar from January 2012 to December2016 . Eligible patients were included in the study through cardiology out patientdepartment. Patients with other causes of raised PAP were excluded. Diagnosiswas made by transthoracic echocardiography while size of defect was measuredwith trans-esophageal echocardiography. Pulmonary artery pressures (PAP)were measured with right heart catheterization. The data was analyzed by SPSS20. Correlation of age and ASD size with PAP groups were examined by Pearsoncorrelation (2-tailed) and R value was calculated.

Result: A total of 104 consecutive patients were included with 65.4 % offemales. Mean age and defect size were 23.25 ± 12.2 years and 23.36 ± 5.81mm, respectively. Average systolic and mean PAP were 37.88±12.3 and 24.48± 8.19 mmHg, respectively with 49 (47.1%) patients had raised PAP. Age andsize were positively correlated with systolic (R=0.220 & 0.198) and mean PAP(R=0.288 & 0.218) respectively , with most significant results in second andthird decade of life and defect size of>20mm(p <0.002).

Conclusion: Age and ASD size were positively correlated with pulmonary arterypressure. Moreover PAP can be predicted by the age of patients with ASDsecundum.