Evaluation of Concentrated Growth Factor and Advanced PlateletRich Fibrin around peri-implant tissues in Maxillary Anterior Region

Abstract

Abstract
Background: The success of dental implant placement in the maxillary anterior region is
closely tied to the preservation and enhancement of peri-implant soft and hard tissues.
Advanced Platelet-Rich Fibrin (A-PRF) and Concentrated Growth Factor (CGF) are two
promising autologous bioactive materials known for their potential in tissue regeneration.
This study aims to assess the impact of A-PRF and CGF on the tissues surrounding dental
implants in the maxillary anterior region.Materials and Methods:A total of 30 patients
requiring dental implant placement in the maxillary anterior region were selected for this
randomized controlled clinical trial. Patients were divided into three groups: Group A (APRF), Group B (CGF), and Group C (Control). Preoperative baseline measurements of soft
tissue thickness (STT) and bone density (BD) were recorded using standardized clinical and
radiographic techniques. Following dental implant placement, A-PRF and CGF were applied
in Groups A and B, respectively, while Group C received no additional treatment.
Postoperative measurements were recorded at 3, 6, and 12 months. Statistical analysis was
performed using ANOVA and Tukey's post hoc test.Results:At 12 months post-implantation,
Group A (A-PRF) exhibited a significant increase in soft tissue thickness (STT) compared to
Group B (CGF) and Group C (Control) (p < 0.05). Group B showed a notable improvement
in bone density (BD) at 12 months compared to Group A and Group C (p < 0.05). Both APRF and CGF groups demonstrated significantly better outcomes in terms of soft tissue
stability and bone density when compared to the control group.Conclusion:The application
of Advanced Platelet-Rich Fibrin (A-PRF) and Concentrated Growth Factor (CGF) around
dental implants in the maxillary anterior region has a positive and significant impact on the
preservation and enhancement of peri-implant soft and hard tissues. A-PRF appears to be
more effective in improving soft tissue thickness, while CGF shows promise in enhancing
bone density. These autologous bioactive materials can be valuable adjuncts to implant
dentistry procedures in achieving optimal esthetic and functional outcomes.
Keywords: dental implants, advanced platelet-rich fibrin, concentrated growth factor, tissue
regeneration, maxillary anterior region, soft tissue thickness, bone density, clinical trial.