ASSESSMENT OF RISK FACTORS ASSOCIATED WITH PCOS IN PREMENOPAUSAL WOMEN IN A TERTIARY CARE CENTRE

Abstract

Introduction: PCOS is a heterogeneous endocrine disorder seen in women of reproductive age. It causes abnormality like polycystic ovaries, hyperandrogenism and irregular menstrual cycle. PCOS is thought to be associated with risk factors like Type 2 Diabetes mellitus. It is also associated with risk factors which can be life threatening.

 Aim: The aim of the current study was to analyze and correlate the biochemical parameters and hormonal parameters of women with PCOS and to identify the risk factors associated with PCOS

 Material & Methods: Group I comprising of 70 women with PCOS; Group II with 70 women without PCOS were included in the present study. Blood samples from participants of both groups were assessed for biochemical parameters like FBS, Lipid profile, uric acid and hormonal parameters like TSH, prolactin, insulin & HOMA-IR. Premenopausal women in the age range of 18-40yrs diagnosed with PCOS Patients with diabetes mellitus, hypertension, thyroid disorders, cardiovascular disease, Cushing’s syndrome, pregnant or lactating women and women on medication for oral contraception, hypoglycemic, lipid lowering drugs, hormonal medications within previous 6 weeks were excluded from the present study

 Results: The participants of the study were 100% females and in the age group of 18-40years.There was a positive correlation of FBS and Lipid profile among Group I and Group II and the p value was <0.05. Serum uric acid was found to be in normal range in both patients with p value of 0.606. Serum TSH level, Prolactin level, serum insulin level and HOMA-IR were significantly increased in women with PCOS than in healthy controls and the p value was <0.05.

 Conclusion: The use of   simple and cost-effective biochemical parameters might prove to be biomarkers in early detection of these metabolic changes and may help to identify women with PCOS and the associated risk factors.