Investigating the effect of Habolzahab (Iranian medicinal products based on Sabr, Hallila and rose flower) on the intraocular pressure of patients with open-angle glaucoma: A randomized, double-blind clinical trial

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Ebrahim Heidari
Assie Jokar
Ebrahim Nasiri
Kiumars Nowroozpoordailami


Introduction: Glaucoma is the name of a group of diseases that is characterized by irreversible optic neuropathy, which is in the form of depression and analysis of the connective and nerve tissue elements of the optic disc, which ultimately causes a specific pattern of visual impairment, in the form of loss of the visual field and blindness becomes. Scholars of traditional medicine had opinions and opinions in the field of recognition, description and treatment of eye diseases and definitions of functional terms, and almost all traditional medicine books deal with the diagnosis and treatment of eye diseases. The purpose of this research was to explain the glaucoma disease in Iranian medicine and compare the medicine of Hab-al Zahab with routine drugs on the intraocular pressure and symptoms of patients with glaucoma. In order to have a positive effect, this medicine can be recommended as a natural product made in Iran, for auxiliary treatment in patients.

materials and methods:This study was done in two stages, in the first stage of this study, there was a library of text analysis type And in the second step of this study, it was a double-blind clinical trial research. All patients aged 18-75 who referred to the eye clinic of Bo Ali Hospital were included in the study according to the inclusion and exclusion criteria. Data collected from patients who had a confirmed diagnosis by an optometrist and had chronic glaucoma under routine treatment. They were entered into spss21 software and analyzed.

 Results: The results of data analysis showed that the average weight of the studied patients was 71.6±10.3 and the average height was 166.1±7.4 and their average age was 47.6±13.6 years. 67.6% were women, 50% had a diploma or lower education level.88.2% had no history of eye surgery. 51.5% had House keeping, 82.4% did not consume alcohol. The simultaneous effect of time in the studied groups and based on the Greenhouse test shows that there is no significant difference between the left eye pressure in the intervention and control groups (p<0.222), The right eye pressure simultaneously in the study groups. And in the passage of time, they have a statistically significant difference (p<0.042), There is a significant difference in the frequency of Shedding tears in the intervention and control groups (p<0.031), There is no significant difference in the frequency of blurred vision in both groups (p<0.374), The simultaneous effect of group and time shows a significant difference between the two groups of abdominal pain (p=0.019), There is a significant difference in the rate of constipation reduction in both groups (p<0.014).

If additional studies are confirmed, the use of habolzahb drug can reduce intraocular pressure in the long term as an adjunctive treatment along with routine drugs.

Conclusion: Medicinal plants along with latanoprost, timolol and dorzolamide drugs reduce intraocular pressure in people suffering from this disease.

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