A PROSPECTIVE OBSERVATIONAL STUDY FOR THE ASSESSMENT OF MEAN PLATELET VOLUME IN ACUTE CORONARY SYNDROME PATIENTS

Abstract

BACKGROUND:

Acute coronary syndrome refers to group of clinical signs and symptoms which includes unstable angina, Non ST segment elevation myocardial infarction(NSTEMI), ST segment elevation myocardial infarction(STEMI). Due to rupture of plaque and results in the coronary thrombus formation. Platelet play a major role in initiation of thrombosis. MPV is useful biomarker for the activity of platelets. Elevated MVP is associated with impaired angiographic perfusion in ACS patients.

AIM:
To evaluate the levels of mean platelet volume in ACS patients.
METHODS:

Prospective observational study was done in 500 patients, Complete clinical details    of patients were taken. Blood investigations were done as a part of routine investigation. Platelet count and MPV were determined using STKS automated hematology analyzer (Beckman coulrter). Mean platelet volume is statistically analyzed using Pearson correlation  between ACS and control groups and One way ANOVA test between ACS groups.

RESULT:

A total number of  250 cases with ACS and 250 normal healthy individuals were taken up for the study. About 85% of patients with ACS had significantly elevated MPV value compared   with control groups. Among ACS groups significant difference was obtained with elevated MPV in STEMI patients compared to NSTEMI and UA.

CONCLUSION:

MPV value was significantly higher in ACS patients and MPV values vary   significantly between ACS groups. Hence it can be used as reliable marker for early risk stratification of ACS.