OUR EXPERIENCE WITH THE USE OF PLATELET RICH PLASMA IN NON-HEALING DIABETIC ULCERS

Abstract

In several areas of medicine, including tissue regeneration, platelet-rich plasma (PRP) is frequently employed. Its primary uses in dermatology over the past few years have primarily been in the treatment of wrinkles and wound healing. PRP is a source of growth factors since it has higher concentrations of platelets than whole blood. Chronic wounds are characterised by a protracted inflammatory phase that involves ongoing degradation of growth factors and matrix proteins. The cell migration, proliferation, and differentiation that are necessary for wound healing are facilitated by growth factors. We intend to provide an updated critical assessment of the clinical evidence that supports the utility of PRP for the therapeutic challenge that chronic ulcers represent in this review by outlining the fundamental principles of PRP in wound healing.