CORRELATION OF MEAN HBA1C LEVELS WITH SEVERITY OF CORONARY ARTERIES DISEASE IN DIABETICS

Abstract

Objective: The aim of this study was to know the correlation of mean HbA1c
levels with severity of coronary arteries disease (CAD) in diabetics.
Methodology: This descriptive cross sectional study was conducted at Punjab
Institute of Cardiology, Lahore from May 2011 to November 2011 including 228
patients, 30 to 70 years of age with the diagnosis of ACS or stable angina and no
contraindication to coronary angiography. HbA1c levels were measured in all
patients. Severity of CAD was determined on the basis of number of coronary
arteries involved and patients were divided into three groups i.e. mild, moderate
and severe CAD. Mean HbA1c values were then compared in all three groups to
determine the correlation HbA1c levels with severity of CAD.
Results: The mean age of study population was 51.5±9.5 years. Males were
151(65.7%). Mild CAD patients were 89(38.7%), 71(30.9%) were moderate
disease while 70(30.4%) had severe CAD. Hypertensive patients were
128(55.7%), 52(22.6%) were smokers, 82(35.7%) were dyslipidemic and
26(11.3%) patients had positive family history of premature CAD. Mean HbA1c
of the study population was 9.1±1.02 (8.1±0.37 in mild CAD group, 9.1±0.50
in moderate and 10.3±0.53 in severe CAD group. Severity of coronary artery
disease increases with increase in Hemoglobin A1c level(p<0.0001). Patients
with high HbA1c levels have more number of coronaries diseased as compared
to those who have lower levels.
Conclusion: HbA1c is directly related to severity of coronary artery disease;the
more the HbA1c level the more severe is the coronary artery disease.