IMPACT OF COMBINED WHITE BLOOD CELL COUNT AND PLASMA GLUCOSE FOR PREDICTING IN-HOSPITAL OUTCOMES AFTER ACUTE MYOCARDIAL INFARCTION

Abstract

Objective: To determine the combined effects of WBC count and Plasma Glucose
levels on predicting in-hospital outcomes in patients with acute myocardial
infarction.

Methodology: This cross-sectional study was conducted at Liaquat University of
medical and health sciences Hyderabad between the periods of 12 months (1 st
January 2011 to 31 st December 2011). All consecutive patients with acute
myocardial infarction with age ≥ 18 years of either sex were included. White
blood cell count and plasma glucose levels were measured and compared their
relationship with in-hospital mortality rates. SPSS version 16 was used for data
entrance and analysis. A p value of <0.05 were considered statistically
significant.

Results: Among 916 patients, the mean age of the patients ± standard deviation
was 60 ± 2 years with predominant male proportion (74%). Majority of them
(60%) were diagnosed as acute anterior wall myocardial infarction. Overall inhospital mortality rate was 109 (12%). In-hospital mortality rate was significantly
higher observed in patients with a higher count of WBC and elevated levels of
plasma glucose (p<0.05).

Conclusion: Patients with hyperglycemia and raised WBC count at the time of
hospitalization with acute myocardial infarction had an increased in-hospital
mortality rate. A step wise increase in peak creatinine kinase level and a step wise
decrease in left ventricular ejection fraction were also observed in patients with
high PG levels with high WBC count.