GENDER EFFECT ON ELECTIVE PERCUTANEOUS CORONARY INTERVENTION (PCI) OUTCOME IN ACUTE CORONARY SYNDROME

Abstract

Objective: This study examined the effect of female gender on Procedural
success, in-hospital and six month adverse cardiac event rates following elective
percutaneous coronary intervention in acute coronary syndrome.
Methodology: This prospective, multi-center and descriptive study conducted at
Karachi Pakistan from July 2010 to March 2012. A total 312 acute coronary
syndrome (ACS) patients who underwent elective coronary angioplasty with
stent were included in study. Patients underwent primary PCI were excluded.
Procedure success defined as when there was less than 10% post-dilated stent
stenosis without complication. In-hospital and six month follow up adverse
event rates was the combined rate of death, myocardial infarction, stroke, heart
failure, CABG or repeat PCI.
Results: Compared with men with ACS (n=190,60.9%), women
(n=122,39.1%) were older and more often had hypertension, diabetes mellitus,
dyslipidemia, and unstable angina (p<0.001 for all), whereas multi-vessel
disease was less frequent (p<0.01). Procedure success in male and female was
97.6% and 96.7% respectively. In-hospital mortality rates for elective PCI were
low and comparable. In hospital and six months after the procedure there were no
gender differences for cardiac death, myocardial infarction, or percutaneous
revascularization for men and women, respectively.
Conclusion: Women undergoing elective coronary angioplasty with stent for
acute coronary syndrome have a higher baseline risk characteristics , whereas
procedural success, in hospital and six month adverse event rates were similar.