ASSOCIATION BETWEEN SERUM URIC ACID AND C-REACTIVE PROTEIN WITH METABOLIC SYNDROME RISK FACTORS -A CROSS SECTIONAL STUDY

Abstract

Objective: To examine the relationship of Serum uric acid (SUA) and C-reactiveprotein (CRP) with the components of metabolic syndrome and association withcardiometabolic risk factor.

Methodology: This cross-sectional study was conducted in Kinnaird College forWomen, Lahore, Pakistan from 1st October 2016 to 31st March 2017, includedsubjects, individuals with metabolic syndrome (MetS), individuals with elevateduric acid level (pre-MetS) and non-metabolic syndrome control samples (Non-MetS) between the age group of 30-70 years. MetS was defined with the help ofInternational diabetes Federation (IDF) criteria. All the required information of theparticipants was collected through structured questionnaire. Data ofanthropometric measurements and blood pressure was gathered from thehospital and tests for fasting glucose and serum lipid profile, serum uric acid andC-reactive protein were conducted in the laboratory.

Results: Total of 90 individuals and 30 control samples (Non-MetS) includedin the study , 40 of metabolic syndrome and 20 with raised uric acid levels. Serumuric acid was significantly associated with cholesterol, LDL-C, triglyceride andVLDL in MetS patients (p<0.005). C-reactive protein in metabolic syndromepatients shared significant relationship with obesity (p<0.001), fasting glucose(p<0.046) and hypertension (p<0.001). Uric acid shared a significantcorrelation with the BMI (p=0.001) in pre-MetS group. group uric acid shareda significant correlation with the BMI (p=0.001). The elevated C-reactiveprotein had a significant association with obesity and uric acid (p<0.001,p=0.041 respectively). Presence of both uric acid and CRP increased the riskof developing MetS after making adjustments (OR: 3.06 95 %Cl: 1.043-8.98).

Conclusion: Elevated levels of serum uric acid (SUA) and C-reactive protein(CRP) have a strong association with metabolic syndrome components.