JAUNDICE AND SINUS BRADYCARDIA 100 YEARS OF AN UNSOLVED MYSTERY

Abstract

The association of cholestatic jaundice and bradycardia is widely accepted. Several reports have documented
a variety of arrhythmias including sinus bradycardia and cardiac asystole in patients with fulminant
hepatitis. However the exact mechanism by which jaundice leads to development of bradycardia is stilI not
known even after hundred years of publication of a land mark study in this connection by John. H. King in
1909. We report a case of severe bradycardia associated with fulminant Hepatitis E in a post-partum lady
with review of literature.