TNF-α, INTERLEUKIN-6, NT-PRO BNP CORRELATION WITH ECHOCARDIOGRAPHY FINDINGS IN PATIENTS WITH THALASSEMIA

Abstract

Objective: To investigate the possible relationship between TNF-α, Interleukin-6,NT-pro BNP, leptin and ferritin with echocardiography findings in thalassemiapatients compared to controls.

Methodology: This case control study was performed on patients and controlsfrom 1st January to 31st December, 2017. Blood samples were taken fromparticipants in fasting to measure Leptin, Ferritin, TNF-α, NT-pro BNP and IL-6serums. Participants underwent echocardiography by pediatric cardiologist. Thelevel of error considered as 0.05 for data analysis by SPSS version 20.0.

Results: There were 112 cases and 114 controls. Mean age of participants was16.09±7.11 years. NT-pro BNP, TNF-α, IL-6, and Ferritin were different inpatients compared to control but leptin was same. Left DT was higher in patients.All echo modalities including A and E, doppler velocities, EF, FS, heart rate, leftPeak E/A, right Peak E/A , LA/Ao in diastole, and in systole ,LVMI, MPI left, MPIright and BMI were different in patients and controls(p<0.05). In patients, NT-proBNP, leptin, TNF-α, Interleukin and ferritin did not correlate to each other exceptTNF-α and IL-6(p=0.001).

Conclusion: NT-pro BNP, TNF-α, IL-6, Ferritin were higher in cases and theycorrelated with some of echocardiography findings whereas leptin was same incase and controls and correlated with ECG findings only. The findings of the studysuggested that NT-pro BNP maybe the best bio marker for evaluation of cardiacfunction in thalassemia patients.