CORONARY ARTERY DISEASE IN PREMENOPAUSAL WOMEN

Abstract

Objective: To determine the frequency of coronary artery disease inpremenopausal women.

Methodology: This cross sectional study included premenopausal women (aged18-40 years) of any parity presenting in Cardiology Emergency Department ofChaudry Pervaiz Elahi Institute of Cardiology, Multan, from 26 July to 25th November2018, were included in the study by non probability, consecutive sampling with chestpain and breathlessness were included in this study. These patients receivedstandard cardiac care and underwent coronary angiography where diagnosis ofCAD was confirmed.

Results: Total of 375 patients were included. Coronary artery disease (CAD) wasdiagnosed in 147 (39.20%) patients on coronary angiography (CAG). Diabeteswas diagnosed in 81 (59.6%) patients having CAD and in 55 (40.4%) patientswithout CAD (p<0.0001). Hypertension was diagnosed in 89 (50.6%) patientswith CAD and in 58 (29.1%) patients without CAD (p<0.0001). Meantriglycerides in CAD patients was 1.82+0.52 mmol/L versus 1.41+0.52mmol/L in non-CAD patients (p<0.0001).

Conclusion: There is a high prevalence of coronary artery disease insymptomatic pre-menopausal women. Diabetes, hypertension and elevatedserum triglyceride levels are associated with higher prevalence of CAD.