Protein C And Protein S Functions In Essential Hypertension

Abstract

Summary: Both protein C and protein S are vitamin K-dependent proteins that are central to the natural anticoagulant pathway involving activated protein C. This pathway not only inhibits blood coagulation but also stimulates fibrinot sis. Arterial hypertension increases the risk of cerebral, coronary, and other vascular complications that frequently involve platelet activation and blood coagulation.

Methods:
The purpose of this study was to determine protein C and protein S activity in patients with essential hypertension compared to normotensive subjects. Protein C and protein S activities were studied in 30 patients with mild to moderate essential hypertension (mean age±SD:54.2±7.2 years) and 30 normotensive subjects (mean agekSD:53.7±7.3 years) of the same essential hypertension, itsclf may causc ccrebral auid coronary ischemia, and other vascular complications by increased coagubility which occurs in the state of decreased protein C and protein S functions